منابع مشابه
Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes.
Recent papers have described the first application of high-throughput sequencing (HTS) technologies to the characterization of transcriptomes. These studies emphasize the tremendous power of this new technology, in terms of both profiling coverage and quantitative accuracy. Initial discoveries include the detection of substantial new transcript complexity, the elucidation of binding maps and re...
متن کاملEnhanced Iterative-Deepening Search
|Iterative-deepening searchesmimic a breadthrst node expansion with a series of depthrst searches that operate with successively extended search horizons. They have been proposed as a simple way to reduce the space complexity of bestrst searches like A* from exponential to linear in the search depth. But there is more to iterative-deepening than just a reduction of storage space. As we show, th...
متن کاملIterative Deepening Multiobjective A
Many real-world optimization problems involve multiple objectives which are often conflicting. When conventional heuristic search algorithms such as A* and IDA* are used for solving such problems, then these problems have to be modeled as simple cost minimization or maximization problems. The task of modeling such problems using a single valued criterion has often proved difficult [6]. The prob...
متن کاملAdaptive Parallel Iterative Deepening
Many of the artiicial intelligence techniques developed to date rely on heuristic search through large spaces. Unfortunately, the size of these spaces and the corresponding computational eeort reduce the applicability of otherwise novel and eeective algorithms. A number of parallel and distributed approaches to search have considerably improved the performance of the search process. Our goal is...
متن کاملStructural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
RlmCD has recently been identified as the S-adenosyl methionine (SAM)-dependent methyltransferase responsible for the formation of m5U at U747 and U1939 of 23S ribosomal RNA in Streptococcus pneumoniae. In this research, we determine the high-resolution crystal structures of apo-form RlmCD and its complex with SAH. Using an in-vitro methyltransferase assay, we reveal the crucial residues for it...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2006
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb600407u